Therapeutic evaluation of topical treatment in mild to moderate plaque psoriasis: clinical experience

Abstract

Plaque psoriasis is a chronic, immune-mediated inflammatory dermatosis with a recurrent course, characterised by keratinocyte hyperproliferation and dysregulation of the cutaneous immune response, with an estimated global prevalence of 2–3% of the population. Mild to moderate forms represent the most common clinical presentation and, although they do not pose an immediate threat to survival, are associated with a substantial burden of physical symptoms, psycho-emotional impairment and reduced quality of life. Within this clinical context, topical therapy remains the first-line therapeutic strategy according to the major international dermatological guidelines. The analysis focuses on the available scientific evidence and the clinical experience documented in the specialised literature regarding the efficacy, safety and clinical applicability of topical treatment in mild to moderate plaque psoriasis. A qualitative, analytical and documentary methodological approach was adopted, based on the systematic organisation of relevant scientific production and conducted in accordance with PRISMA guidelines, without the use of empirical instruments or direct measurement of clinical variables. The integration of the reviewed studies indicates that topical therapy continues to represent the cornerstone of therapeutic management, showing favourable outcomes in the control of cutaneous inflammation and a generally acceptable safety profile, particularly in patients with limited skin involvement, underscoring the importance of individualised therapeutic selection in dermatological practice.