Evaluación experimental de nanopartículas como vehículos de administración controlada de fármacos: resultados preliminares in vitro
DOI:
https://doi.org/10.63969/1731fm30Palabras clave:
Nanopartículas, Liberación de fármacos, PLGA, Sílice mesoporosa, Liberación controladaResumen
El desarrollo de sistemas de liberación de fármacos basados en nanotecnología ha transformado las estrategias terapéuticas al permitir intervenciones farmacológicas más precisas y eficientes. Este estudio presenta una evaluación comparativa in vitro de tres plataformas de nanopartículas—PLGA, lipídicas y de sílice mesoporosa—como vehículos para la liberación controlada de medicamentos. Las formulaciones se caracterizaron según su tamaño, potencial zeta, cinética de liberación en pH fisiológico y ácido, estabilidad térmica y absorción celular. Las nanopartículas de PLGA mostraron una liberación óptima en condiciones ácidas, lo que las posiciona como candidatas ideales para terapias dirigidas a tumores. Las nanopartículas lipídicas ofrecieron mayor biocompatibilidad y eficiencia de captación, mientras que las de sílice mesoporosa destacaron por su resistencia térmica y retención prolongada del fármaco. La integración de inteligencia artificial en la modelación de perfiles de liberación respalda la confiabilidad predictiva de los datos obtenidos. Los hallazgos subrayan el potencial de los sistemas nanoportadores diseñados a medida para mejorar la biodisponibilidad, estabilidad y precisión en la liberación de fármacos, sentando las bases para futuras investigaciones in vivo y clínicas.
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Derechos de autor 2025 Edna Mariana Martínez López, Jorge Angel Velasco Espinal, Ana Paula Calderón Aguirre, Sofía Viramontes Martínez, Alexa Fernanda Uriostegui Navarro, Pablo Manuel Cervantes Barreto (Autor/a)
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
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